Which disease is characterized by decreased elasticity of the skin?

Cushing's Disease leads to a range of systemic effects due to an excess of cortisol in the body. One of the hallmark signs of this disease is the degradation of collagen and elastin fibers within the skin, which notably reduces the skin's elasticity. This can result in thin, fragile skin that is prone to bruising and tearing, as well as a characteristic appearance of the skin that is often referred to as "pendulous" or "atrophic."

In contrast, other options such as hypothyroidism, diabetes mellitus, and hyperthyroidism are associated with different skin conditions or changes. Hypothyroidism may lead to thickened skin and myxedema, while hyperthyroidism can sometimes cause warm, moist skin but does not primarily affect elasticity. Diabetes mellitus might lead to certain skin changes, such as dryness or poor wound healing, but does not specifically result in decreased elasticity in the same pronounced way as Cushing’s disease. Thus, the unique feature of decreased skin elasticity is most clearly associated with Cushing's Disease.