Which chemotherapy drug is known to cause cystitis?

Cyclophosphamide is known to cause cystitis as a result of its metabolite, acrolein, which can irritate the bladder lining. This irritation can lead to inflammation and infection, manifesting as symptoms of cystitis. In veterinary medicine, it's important to monitor patients receiving cyclophosphamide for signs of urinary discomfort or frequent urination, as proactive measures may be needed to protect the bladder, such as hydration or administering protective agents like mesna. Understanding these side effects is crucial for managing the health of animals undergoing chemotherapy.