What clinical sign is associated with cat scratch fever?

Cat scratch fever, primarily caused by Bartonella henselae, is associated with a variety of clinical signs. The disease often begins with localized swelling at the site of the scratch or bite from an infected cat, which is a hallmark sign that helps in identifying the condition. While generalized red rash can occur, it is not the most distinctive feature of cat scratch fever, making it less accurate as a primary clinical sign.

The fever and malaise, along with gastrointestinal upset, are symptoms that can occur but are typically part of a broader systemic response and don't encompass the primary signs associated with cat scratch fever itself. In particular, pustular lesions on the hands and feet are not characteristic of this infection.

The localized swelling at the site of the scratch is the most typical and directly associated symptom of cat scratch fever, as it indicates the immune response to the infected area, making it a critical sign in diagnosing the illness. Thus, while the generalized rash is related to the infection, it doesn't specifically pinpoint cat scratch fever as effectively as the localized swelling.